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Page 1
Sarcopenia.
Tournadre A, Vial G, Capel F, Soubrier M, Boirie Y. Tournadre A, et al. Joint Bone Spine. 2019 May;86(3):309-314. doi: 10.1016/j.jbspin.2018.08.001. Epub 2018 Aug 8. Joint Bone Spine. 2019. PMID: 30098424 Review.
Sarcopenia results from complex and interdependent pathophysiological mechanisms that include aging, physical inactivity, neuromuscular compromise, resistance to postprandial anabolism, insulin resistance, lipotoxicity, endocrine factors, oxidative stress, mitochondrial dysfuncti …
Sarcopenia results from complex and interdependent pathophysiological mechanisms that include aging, physical inactivity, neuromuscular comp …
Understanding of sarcopenia: from definition to therapeutic strategies.
Kim JW, Kim R, Choi H, Lee SJ, Bae GU. Kim JW, et al. Arch Pharm Res. 2021 Oct;44(9-10):876-889. doi: 10.1007/s12272-021-01349-z. Epub 2021 Sep 18. Arch Pharm Res. 2021. PMID: 34537916 Review.
Sarcopenia is caused by multiple factors such as reduced regenerative capacity, imbalance in protein turnover, alteration of fat and fibrotic composition in muscle, increased reactive oxygen species, dysfunction of mitochondria and increased inflammation. Based on these me …
Sarcopenia is caused by multiple factors such as reduced regenerative capacity, imbalance in protein turnover, alteration of fat and fibroti …
Handelin alleviates cachexia- and aging-induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation.
Zhang HJ, Wang BH, Wang X, Huang CP, Xu SM, Wang JL, Huang TE, Xiao WL, Tian XL, Lan XQ, Wang QQ, Xiang Y. Zhang HJ, et al. J Cachexia Sarcopenia Muscle. 2024 Feb;15(1):173-188. doi: 10.1002/jcsm.13381. Epub 2023 Nov 27. J Cachexia Sarcopenia Muscle. 2024. PMID: 38009816 Free PMC article.

Handelin also reduced lipid peroxidation and protein carbonylation, downregulated mRNA levels of Fbxo32, Mstn, Cxcl1, Il1b and Tnf (P < 0.05), and decreased IL-1beta levels in serum (P < 0.05). ...CONCLUSIONS: Handelin ameliorated cachexia- and aging-induced skeletal

…
Handelin also reduced lipid peroxidation and protein carbonylation, downregulated mRNA levels of Fbxo32, Mstn, Cxcl1, Il1b and Tnf (P …
Myostatin: a potential therapeutic target for metabolic syndrome.
Yang M, Liu C, Jiang N, Liu Y, Luo S, Li C, Zhao H, Han Y, Chen W, Li L, Xiao L, Sun L. Yang M, et al. Front Endocrinol (Lausanne). 2023 May 23;14:1181913. doi: 10.3389/fendo.2023.1181913. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37288303 Free PMC article. Review.
In this review, we describe the transcriptional regulation and receptor binding pathway of MSTN, then introduce the role of MSTN in regulating mitochondrial function and autophagy, review the research progress of MSTN in metabolic syndrome. Finally summarize …
In this review, we describe the transcriptional regulation and receptor binding pathway of MSTN, then introduce the role of MSTN …
Enhanced myostatin expression and signalling promote tubulointerstitial inflammation in diabetic nephropathy.
Verzola D, Milanesi S, Viazzi F, Ansaldo F, Saio M, Garibaldi S, Carta A, Costigliolo F, Salvidio G, Barisione C, Esposito P, Garibotto G, Picciotto D. Verzola D, et al. Sci Rep. 2020 Apr 14;10(1):6343. doi: 10.1038/s41598-020-62875-2. Sci Rep. 2020. PMID: 32286342 Free PMC article.
MSTN was also upregulated in the glomeruli and the arterial vessels. ...Our results also show that MSTN is a strong inducer of proximal tubule activation and suggest that MSTN overexpression contributes to kidney interstitial fibrosis in DN....
MSTN was also upregulated in the glomeruli and the arterial vessels. ...Our results also show that MSTN is a strong inducer of …
Myostatin and muscle atrophy during chronic kidney disease.
Bataille S, Chauveau P, Fouque D, Aparicio M, Koppe L. Bataille S, et al. Nephrol Dial Transplant. 2021 Nov 9;36(11):1986-1993. doi: 10.1093/ndt/gfaa129. Nephrol Dial Transplant. 2021. PMID: 32974666 Review.
Most studies report higher Mstn concentrations in CKD and dialysis patients than in healthy subjects. Several factors increase Mstn production in uraemic conditions: low physical activity, chronic or acute inflammation and oxidative stress, uraemic toxins, an …
Most studies report higher Mstn concentrations in CKD and dialysis patients than in healthy subjects. Several factors increase Mst …
Joint inflammation alters gene and protein expression and leads to atrophy in the tibialis anterior muscle in rats.
Ramírez C, Russo TL, Sandoval MC, Dentillo AA, Couto MA, Durigan JL, Salvini TF. Ramírez C, et al. Am J Phys Med Rehabil. 2011 Nov;90(11):930-9. doi: 10.1097/PHM.0b013e31822dea3c. Am J Phys Med Rehabil. 2011. PMID: 21959222
RESULTS: At 2 days, the inflammation group increased atrogin-1, MuRF1, and myostatin and reduced MyoD expression. ...At 15 days, gene and protein expression in the inflammation group returned to basal levels, and CSA values were similar to those in control and sham …
RESULTS: At 2 days, the inflammation group increased atrogin-1, MuRF1, and myostatin and reduced MyoD expression. ...At 15 days, gene …
[Genetics in sports-muscle injuries].
Pfab F, Sieland J, Haser C, Banzer W, Kocher T. Pfab F, et al. Orthopadie (Heidelb). 2023 Nov;52(11):889-896. doi: 10.1007/s00132-023-04439-6. Epub 2023 Sep 29. Orthopadie (Heidelb). 2023. PMID: 37773215 Review. German.
SPECIFIC GENES: Several genes have been linked to muscle injury, such as myostatin (MSTN), insulin-like growth factor 1 (IGF-1), and several collagen genes (COL). In addition to genes involved in muscle development, growth, and repair, genes involved in inflammation …
SPECIFIC GENES: Several genes have been linked to muscle injury, such as myostatin (MSTN), insulin-like growth factor 1 (IGF-1), and …
Emerging role of myostatin and its inhibition in the setting of chronic kidney disease.
Verzola D, Barisione C, Picciotto D, Garibotto G, Koppe L. Verzola D, et al. Kidney Int. 2019 Mar;95(3):506-517. doi: 10.1016/j.kint.2018.10.010. Epub 2018 Dec 28. Kidney Int. 2019. PMID: 30598193 Free article. Review.
In all these conditions wasting is an effect of the activation of protein degradation in muscle, a response that increases the risk of morbidity and mortality. Major recent advances in our knowledge on how CKD and inflammation affect cellular signaling include the identifi …
In all these conditions wasting is an effect of the activation of protein degradation in muscle, a response that increases the risk of morbi …
69 results